Granulosa Cell Tumor

Abstract

Introduction: The granulosa cell tumor represents 2 - 5% of ovarian neoplasms. Although its symptoms are due to the increase in estradiol secreted by the tumor, on many occasions it exhibits with very nonspecific symptoms. The diagnosis of suspicion is
based on the combination of the symptoms with compatible imaging tests and the determination of inhibin. Its management is controversial. The standard surgical approach is a complete resection that includes total abdominal hysterectomy, bilateral salpingo-oophorectomy, and surgical stratification. The stage of the disease has been shown to be the most important prognostic factor in terms of survival.
Objectives: To present a series of clinical cases with granulosa cell tumors to determine the various forms of presentation, and to establish unified diagnosis and treatment protocols, based on an exhaustive bibliographic review.
Methods: A search was carried out in the Medline databases via PubMed with the key words "granulosa cell tumor; stromal ovarian tumor; ovary carcinoma", from MeSH. Preference is shown for works referring to the diagnosis, treatment and prognosis of this neoplasm.Case report: We present a series of cases of granulosa cell tumors that were diagnosed and treated in our hospital
Conclusions: Granulosa cell tumors are tumors with a low degree of malignancy and preferentially local dissemination. Its prognosis is quite good, with a 10-year survival rate in more than 80% of cases.