Evolution of Adiponectin Levels and Their Relationship with Lipid Profile and Insulin Levels

Abstract

Introduction: Adipose tissue during pregnancy increases its metabolic activity, producing adipocytokines, which exert endocrine and paracrine activities,
therefore, weight gain is normal, however, its deregulation generates diabetes mellitus and preeclampsia among others.
Objective: To determine the evolution of adiponectin levels during normal pregnancy and its relationship with the lipid profile and insulin.
Methods: Fasting blood samples were taken from 73 pregnant women with normal pregnancies, average age of 22 years, during the first, second and third trimester, treated at San Marcos hospital in Chinchiná, Colombia, from November 2017 to June 2018. Adiponectin levels, lipid profile and insulin in blood were determined.
Results: A statistically significant difference was obtained in adiponectin values between the first, second and third trimester of pregnancy. In the lipid profile, a statistically significant difference was found among the different trimesters in the values of triglycerides, total cholesterol and low-density lipoprotein cholesterol. Insulin values were found to be high in all trimesters.
Conclusions: During normal pregnancy, adiponectin values are decreased, with decreasing trend towards the second and third trimester. No correlation was observed among the behavior of adiponectin levels during pregnancy and the other metabolites analyzed