Gestation Rate and βhcg Levels in Frozen and Fresh Embryos Transfer

Abstract

Introduction: In the cycles of ovulation stimulation, the endometrium is subjected to supra-physiological hormone levels that would lead to morphological and biochemical alterations and to an endometrial environment responsible for implantation failure and lower success rates, in addition to an asynchrony with respect to the embryos to transfer. However, this does not happen in frozen embryos transfer (Frozen ET), in which embryos are transferred in an environment that has not suffered deleterious hormonal effects of IVF / ICSI cycles.
Objective: To evaluate if the results are superior in frozen ET cycles and if fresh embryos transfer (TE) can replace the transfer of frozen embryos, and to establish the effectiveness of vitrifying all embryos or "freeze all", as it is known, and transfer them in a second time.
Methods: We compared the epidemiological parameters and the treatment of assisted reproduction, implantation rates, gestation and βHCG levels in 168 patients of cycles of frozen ET and 200 patients of ET cycles, carried out from January 2015 to November 2016. The statistical analysis was performed with the Student's t-test, Chi-square, and ANOVA. (Statistical package SPSS, version 20.0).
Results: There were significant differences in β-HCG serum value that was higher for frozen ET. The positive pregnancy rate was higher for frozen ET, with higher probability of βHCG positive in relation to the TE group. The evolutionary clinical gestation rate did not present significant differences.
Conclusions: Although we found a significant difference in βHCG values in frozen ET, the clinical pregnancy rate and obstetric results did not turn out to be different.